An urgent notification was sent out to Maryland clinicians. From 2016 – 2020, there were 6 confirmed transmissions. During 2021, there were 156 confirmed perinatal HIV exposures and zero cases of perinatal HIV infections in babies born in Maryland. Since July 2022, five babies from four different jurisdictions in the state have acquired HIV through perinatal transmission and a sixth perinatal HIV infection was reported in a young child born several years earlier. All six children are currently in care.